Compounds > 1-[4-(3-chlorophenyl)-1-piperazinyl]-3-(diphenylmethyl)oxy-2-propanol

Page last updated: 2024-08-03 06:07:36

1-[4-(3-chlorophenyl)-1-piperazinyl]-3-(diphenylmethyl)oxy-2-propanol

Description

1-[4-(3-chlorophenyl)-1-piperazinyl]-3-(diphenylmethyl)oxy-2-propanol : no description available [CHeBI]

Cross-References

ID Source	ID
PubMed CID	16290602
CHEMBL ID	1558628
CHEBI ID	115118

Synonyms (9)

Synonym
smr000595532
MLS001177309
CHEBI:115118
CHEMBL1558628
1-[4-(3-chlorophenyl)-1-piperazinyl]-3-(diphenylmethyl)oxy-2-propanol
Q27196963
Z31378992
AKOS034159213
1-benzhydryloxy-3-[4-(3-chlorophenyl)piperazin-1-yl]propan-2-ol

Drug Classes (1)

Class	Description
diarylmethane	Any compound containing two aryl groups connected by a single C atom.

Protein Targets (14)

Potency Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)
Chain A, Ferritin light chain	Equus caballus (horse)	Potency	50.1187	AID485281
glp-1 receptor, partial	Homo sapiens (human)	Potency	10.0000	AID624417
TDP1 protein	Homo sapiens (human)	Potency	21.8528	AID686978; AID686979
Smad3	Homo sapiens (human)	Potency	21.6019	AID588855; AID720534; AID720536; AID720537
PINK1	Homo sapiens (human)	Potency	39.8107	AID624263
nonstructural protein 1	Influenza A virus (A/WSN/1933(H1N1))	Potency	8.9125	AID2326
glucocerebrosidase	Homo sapiens (human)	Potency	14.1254	AID2101
Parkin	Homo sapiens (human)	Potency	39.8107	AID624263
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	Homo sapiens (human)	Potency	50.1187	AID743266
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	Homo sapiens (human)	Potency	89.1251	AID504891
DNA polymerase iota isoform a (long)	Homo sapiens (human)	Potency	100.0000	AID588590
geminin	Homo sapiens (human)	Potency	20.5962	AID624296
DNA dC->dU-editing enzyme APOBEC-3F isoform a	Homo sapiens (human)	Potency	35.4813	AID602313
Guanine nucleotide-binding protein G	Homo sapiens (human)	Potency	4.4668	AID624287

Bioassays (7)

Assay ID	Title	Year	Journal	Article
AID588499	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set	2010	Current protocols in cytometry, Oct, Volume: Chapter 13ISSN: 1934-9300	Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set	2006	Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 ISSN: 1552-4922	Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set	2010	Assay and drug development technologies, Feb, Volume: 8, Issue:1 ISSN: 1557-8127	High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588497	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set	2010	Current protocols in cytometry, Oct, Volume: Chapter 13ISSN: 1934-9300	Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set	2006	Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 ISSN: 1552-4922	Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set	2010	Assay and drug development technologies, Feb, Volume: 8, Issue:1 ISSN: 1557-8127	High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588501	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set	2010	Current protocols in cytometry, Oct, Volume: Chapter 13ISSN: 1934-9300	Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set	2006	Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 ISSN: 1552-4922	Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set	2010	Assay and drug development technologies, Feb, Volume: 8, Issue:1 ISSN: 1557-8127	High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID504810	Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign	2010	Endocrinology, Jul, Volume: 151, Issue:7 ISSN: 1945-7170	A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID1745845	Primary qHTS for Inhibitors of ATXN expression	2022	The Journal of biological chemistry, 08, Volume: 298, Issue:8 ISSN: 1083-351X
AID504812	Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign	2010	Endocrinology, Jul, Volume: 151, Issue:7 ISSN: 1945-7170	A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID651635	Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression	2022	The Journal of biological chemistry, 08, Volume: 298, Issue:8 ISSN: 1083-351X

Research

Studies (5)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (20.00)	29.6817
2010's	3 (60.00)	24.3611
2020's	1 (20.00)	2.80

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	5 (100.00%)	84.16%

Substance	Classes	Roles	Relationship Strength
b 844-39	diarylmethane		low
3-[(4-chlorophenyl)-phenylmethoxy]-8-methyl-8-azabicyclo[3.2.1]octane	diarylmethane		low
adiphenine	diarylmethane		low
3-(2'-aminobenzhydryloxy)tropane	diarylmethane		low
2,2-bis(4-glycidyloxyphenyl)propane	diarylmethane		low
benproperine	diarylmethane		low
cogentin	diarylmethane		low
bifemelane	diarylmethane		low
bisacodyl	diarylmethane		low
chlorcyclizine	diarylmethane		low
cifenline	diarylmethane		low
clidinium	diarylmethane		low
clofedanol	diarylmethane; tertiary amino compound	antitussive	low
clofoctol	diarylmethane		low
cloperastine	diarylmethane		low
r 59022	diarylmethane		low
dichlorophen	bridged diphenyl fungicide; diarylmethane		low
fendiline	diarylmethane		low
1-[bis(4-fluorophenyl)methyl]-4-(3-phenylprop-2-enyl)piperazine	diarylmethane		low
fluspirilene	diarylmethane		low
homochlorocyclizine	diarylmethane		low
isopropamide iodide	diarylmethane		low
lidoflazine	diarylmethane		low
lomerizine	diarylmethane		low
manidipine	diarylmethane		low
meclizine	diarylmethane		low
mepenzolate	diarylmethane		low
methadone	benzenes; diarylmethane; ketone; tertiary amino compound		low
mitotane	diarylmethane		low
no 711	diarylmethane		low
oxatomide	benzimidazoles; diarylmethane; N-alkylpiperazine	anti-allergic agent; anti-inflammatory agent; geroprotector; H1-receptor antagonist; serotonergic antagonist	low
pipenzolate	diarylmethane		low
piperidolate	diarylmethane		low
proadifen	diarylmethane		low
propiverine	diarylmethane		low
aurin	diarylmethane		low
dpi 201-106	diarylmethane		low
terfenadine	diarylmethane		low
isopropamide iodide	diarylmethane		low
mepenzolate bromide	diarylmethane		low
chlorphenoxamine	diarylmethane	anticoronaviral agent	low
chlorfenethol	diarylmethane		low
diphenadione	beta-triketone; diarylmethane		low
phenyltoloxamine	diarylmethane		low
n,n,n',n'-tetramethyl-4,4'-methylenedianiline	diarylmethane		low
diphenan	diarylmethane		low
diphenylmethane	diarylmethane		low
2,2'-methylenebis(4-methyl-6-tert-butylphenol)	diarylmethane		low
piperidolate hydrochloride	diarylmethane		low
benactyzine	diarylmethane		low
prenylamine	diarylmethane		low
isomethadone	diarylmethane		low
pipradrol	diarylmethane		low
normethadone	diarylmethane		low
captodiamine	diarylmethane		low
methadyl acetate	diarylmethane		low
benzomethamine	diarylmethane		low
chlorobenzilate	diarylmethane		low
dimenhydrinate	diarylmethane		low
poldine	diarylmethane		low
thiphenamil	diarylmethane		low
4-cumylphenol	diarylmethane		low
4,4'-bisphenol f	bisphenol; diarylmethane	environmental food contaminant; xenoestrogen	low
o,p'-ddt	diarylmethane		low
4,4'-methylene bis(2-methylaniline)	diarylmethane		low
dipipanone	diarylmethane		low
diphenamid	diarylmethane		low
paracymethadol	diarylmethane		low
bisphenol a-glycidyl methacrylate	diarylmethane		low
azacyclonol	diarylmethane		low
dimenoxadol	diarylmethane		low
amphenone b	diarylmethane		low
propinox	diarylmethane		low
embramine	diarylmethane		low
chlorophacinone	beta-triketone; diarylmethane		low
aminopentamide	diarylmethane		low
octocrylene	diarylmethane		low
terodiline	diarylmethane		low
tofenacin	diarylmethane		low
pipoxolan	diarylmethane		low
penfluridol	diarylmethane		low
emepronium	diarylmethane		low
levomethadyl acetate hydrochloride	diarylmethane		low
flumecinol	diarylmethane		low
setastine	diarylmethane		low
progabide	diarylmethane		low
beclobrate	diarylmethane		low
cetirizine dihydrochloride	diarylmethane		low
niguldipine	diarylmethane		low
terfenadine	diarylmethane		low
mandrax	diarylmethane		low
droprenylamine	diarylmethane		low
quifenadine	diarylmethane		low
carebastine	diarylmethane		low
lercanidipine	diarylmethane		low
diphenidol hydrochloride	diarylmethane		low
dioxadrol	diarylmethane		low
budipine	diarylmethane		low
epicainide	diarylmethane		low
butinoline	diarylmethane		low
denaverine	diarylmethane		low
lifarizine	diarylmethane		low
fenpiverinium	diarylmethane		low
2,2-methylenebis(4-chloro-3-methyl-isopropylphenol)	diarylmethane		low
amperozide	diarylmethane; monofluorobenzenes; N-alkylpiperazine; secondary carboxamide; ureas	anxiolytic drug; dopamine uptake inhibitor; geroprotector; second generation antipsychotic; serotonergic antagonist	low
2,2'-bisphenol f	diarylmethane		low
3-hydroxy-2,2-diphenylpropanoic acid	diarylmethane		low
1,1-Dichloro-2,2-bis(4-hydroxyphenyl)ethylene	diarylmethane		low
bisphenol f diglycidyl ether	aromatic ether; diarylmethane; epoxide		low
n-(4,4-diphenyl-3-butenyl)nipecotic acid	diarylmethane		low
methylene bis(methylanthranilate)	diarylmethane		low
tesmilifene	diarylmethane		low
pd 123177	diarylmethane		low
bw 373u86	diarylmethane		low
gilutensin hydrochloride	diarylmethane		low
4-(alpha-(4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl)-n,n-diethylbenzamide	diarylmethane		low
ae0047	diarylmethane		low
lercanidipine hydrochloride	diarylmethane		low
cloperastine hydrochloride	diarylmethane		low
1,1,1-trichloro-2-(4-hydroxyphenyl)-2-(4-methoxyphenyl)ethane	diarylmethane		low
2-[(4,6-dimethyl-2-pyrimidinyl)oxy]-3-methoxy-3,3-diphenylpropanoic acid	diarylmethane		low
ci 966	diarylmethane		low
Difeterol	diarylmethane		low
1,1-bis(4-hydroxyphenyl)cyclohexane	diarylmethane		low
2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene	diarylmethane		low
N-[2-(dimethylamino)ethyl]-2,2-diphenylacetamide	diarylmethane		low
propiverine hydrochloride	diarylmethane		low
gw 3965	diarylmethane		low
1,1-Bis(4-hydroxyphenyl)ethane	diarylmethane		low
uk 78282	diarylmethane		low
r 59949	diarylmethane		low
4-[1-(4-hydroxyphenyl)ethenyl]phenol	diarylmethane		low
5-[4-(diphenylmethyl)-1-piperazinyl]-2-(2-methoxyphenyl)-4-oxazolecarbonitrile	diarylmethane		low
flunarizine	diarylmethane		low
N-[4-[oxo-[(1-oxo-2,2-diphenylethyl)hydrazo]methyl]phenyl]propanamide	diarylmethane		low
[4-(diphenylmethyl)-1-piperazinyl]-[5-thiophen-2-yl-7-(trifluoromethyl)-3-pyrazolo[1,5-a]pyrimidinyl]methanone	diarylmethane		low
benztropine	diarylmethane		low
3-[[[(1-oxo-2,2-diphenylethyl)amino]-sulfanylidenemethyl]amino]benzoic acid	diarylmethane		low
3-bromo-5-[[4-[hydroxy(diphenyl)methyl]-1-piperidinyl]-oxomethyl]-2-pyranone	diarylmethane		low
2-(5-bromo-3-nitro-1,2,4-triazol-1-yl)-N-(diphenylmethyl)acetamide	diarylmethane		low
1,1-bis(4-chlorophenyl)-2-[(3-methoxyphenyl)methylamino]ethanol	diarylmethane		low
cinnarizine	diarylmethane; N-alkylpiperazine; olefinic compound	anti-allergic agent; antiemetic; calcium channel blocker; geroprotector; H1-receptor antagonist; histamine antagonist; muscarinic antagonist	low
levocetirizine	diarylmethane		low
amn082	benzenes; diamine; diarylmethane; secondary amino compound	metabotropic glutamate receptor agonist; neuroprotective agent	low
N-[2-[tert-butyl(methyl)amino]ethyl]-N-methyl-2,2-diphenylacetamide	diarylmethane		low
N-(4-fluorophenyl)-4-[hydroxy(diphenyl)methyl]-1-piperidinecarbothioamide	diarylmethane		low
4-oxo-3-[(1-oxo-2,2-diphenylethyl)amino]-2-sulfanylidene-1H-quinazoline-7-carboxylic acid methyl ester	diarylmethane		low
2,2-diphenylacetic acid (2,6-dimethylphenyl) ester	diarylmethane		low
1-ethyl-3-[(1-oxo-2,2-diphenylethyl)amino]thiourea	diarylmethane		low
2-(phenylmethyl)benzoic acid [2-[4-(difluoromethylthio)anilino]-2-oxoethyl] ester	diarylmethane		low
2-[2-[bis(4-methoxyphenyl)methylidene]hydrazinyl]benzoic acid	diarylmethane		low
N-[4-bromo-2-[[(2-hydrazinyl-2-oxoethyl)amino]-phenylmethyl]phenyl]-3-(4-morpholinyl)propanamide	diarylmethane		low
N-(4-ethoxyphenyl)-4-[hydroxy(diphenyl)methyl]-1-piperidinecarbothioamide	diarylmethane		low
4-[hydroxy(diphenyl)methyl]-N-(2-phenylethyl)-1-piperidinecarbothioamide	diarylmethane		low
3-(5-chloro-2-hydroxyphenyl)-3-phenyl-N-[(4-propan-2-yloxyphenyl)methyl]propanamide	diarylmethane		low
adrafinil	diarylmethane		low
zamifenacin	diarylmethane		low
2-(cyclohexylamino)-N-[(diphenylmethylene)amino]propanamide	diarylmethane		low
3-[[4-(diphenylmethyl)-1-piperazinyl]-oxomethyl]-7,8,9,10-tetrahydro-6H-azepino[2,1-b]quinazolin-12-one	diarylmethane		low
3-[bis(4-fluorophenyl)methoxy]-8-methyl-8-azabicyclo[3.2.1]octane	diarylmethane		low
flunarizine hydrochloride	diarylmethane		low
(2-amino-5-chlorophenyl)(phenyl)methanone oxime	diarylmethane		low
imidafenacin	diarylmethane		low
2-(3,3-diphenylpropylamino)acetamide	diarylmethane		low
cgk 733	diarylmethane		low
dexniguldipine	diarylmethane		low
lu 208075	diarylmethane		low
fesoterodine	diarylmethane		low
3-(diphenylmethylene)-1-[4-(4-phenyl-1-piperazinyl)butyl]pyrrolidine-2,5-dione	diarylmethane		low
pnu 200577	diarylmethane		low
gc 1 compound	diarylmethane		low
tas 301	diarylmethane		low
1,5-anhydro-1-(5-(4-ethoxybenzyl)-2-methoxy-4-methylphenyl)-1-thioglucitol	diarylmethane		low
[4-(diphenylmethyl)-1-piperazinyl]-(5-methyl-4-nitro-3-isoxazolyl)methanone	diarylmethane		low
1-(1,4-dioxan-2-yl)-N-[[3-(diphenylmethyl)-1,2,4-oxadiazol-5-yl]methyl]-N-methylmethanamine	diarylmethane		low
(8R)-3-[3-[[2-(4-chlorophenoxy)-1-oxoethyl]amino]phenyl]-7-(1-oxo-3,3-diphenylpropyl)-1-oxa-2,7-diazaspiro[4.4]non-2-ene-8-carboxamide	diarylmethane		low
3-(2-hydroxy-4,6-dimethoxyphenyl)-3-(4-methoxyphenyl)-1-(3-methyl-1-piperidinyl)-1-propanone	diarylmethane		low
2-[[[4-[[(diphenylmethyl)amino]-oxomethyl]-1H-imidazol-5-yl]-oxomethyl]amino]acetic acid tert-butyl ester	diarylmethane; tert-butyl ester		low
pf 04971729	diarylmethane		low
ML-210	C-nitro compound; diarylmethane; isoxazoles; monochlorobenzenes; N-acylpiperazine; N-alkylpiperazine; tertiary carboxamide	antineoplastic agent; EC 1.11.1.9 (glutathione peroxidase) inhibitor; ferroptosis inducer; prodrug	low

Condition	Indicated	Studies	First Year	Last Year	Average Age	Relationship Strength	Trials	pre-1990	1990's	2000's	2010's	post-2020
Inflammation	0	1	2010	2010	14.0	high	0	0	0	1	0	0
Innate Inflammatory Response	0	1	2010	2010	14.0	high	0	0	0	1	0	0